ID   RKO FANCC(+/-/-)
AC   CVCL_HE19
SY   FANCC (+/-/-) RKO
DR   cancercelllines; CVCL_HE19
DR   Horizon_Discovery; HD+R05-004
DR   Wikidata; Q54950549
RX   PubMed=16762635;
CC   Characteristics: RKO carries a stable triplication of the FANCC gene.
CC   Knockout cell: Method=Homologous recombination; HGNC; 3584; FANCC (Note=1 of 3 alleles).
CC   Sequence variation: Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11773; TGFBR2; Simple; p.Leu452Pro (c.1355T>C); ClinVar=VCV000930524; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4910; Colon carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0504 ! RKO
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 01-12-16; Last updated: 30-01-24; Version: 12
//
RX   PubMed=16762635; DOI=10.1053/j.gastro.2006.03.016;
RA   Gallmeier E., Calhoun E.S., Rago C., Brody J.R., Cunningham S.C.,
RA   Hucl T., Gorospe M., Kohli M., Lengauer C., Kern S.E.;
RT   "Targeted disruption of FANCC and FANCG in human cancer provides a
RT   preclinical model for specific therapeutic options.";
RL   Gastroenterology 130:2145-2154(2006).
//