| Cell line name |
RKO FANCG(+/-) |
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| Synonyms |
FANCG (+/-) RKO |
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| Accession |
CVCL_HE21 |
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| Resource Identification Initiative |
To cite this cell line use: RKO FANCG(+/-) (RRID:CVCL_HE21) |
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| Comments |
Knockout cell: Method=Homologous recombination; HGNC; 3588; FANCG (Note=1 of 2 alleles).
Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
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| Sequence variations |
- Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11773; TGFBR2; Simple; p.Leu452Pro (c.1355T>C); ClinVar=VCV000930524; Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Colon carcinoma (NCIt: C4910) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0504 (RKO) |
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| Sex of cell |
Sex unspecified |
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| Age at sampling |
Age unspecified |
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| Category |
Cancer cell line |
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| Publications | PubMed=16762635; DOI=10.1053/j.gastro.2006.03.016
Gallmeier E., Calhoun E.S., Rago C., Brody J.R., Cunningham S.C., Hucl T., Gorospe M., Kohli M., Lengauer C., Kern S.E.
Targeted disruption of FANCC and FANCG in human cancer provides a preclinical model for specific therapeutic options.
Gastroenterology 130:2145-2154(2006) |
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| Cross-references |
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| Cell line collections (Providers) |
Horizon_Discovery; HD+R05-002
|
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| Cell line databases/resources |
cancercelllines; CVCL_HE21
|
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| Encyclopedic resources |
Wikidata; Q54950551
|
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| Entry history |
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| Entry creation | 01-Dec-2016 |
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| Last entry update | 30-Jan-2024 |
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| Version number | 11 |
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