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Cellosaurus RKO MIR21(-/-) (CVCL_HE23)

[Text version]

Cell line name RKO MIR21(-/-)
Synonyms MIR21 (-/-) RKO; RKO miR-21 KO
Accession CVCL_HE23
Resource Identification Initiative To cite this cell line use: RKO MIR21(-/-) (RRID:CVCL_HE23)
Comments Knockout cell: Method=Homologous recombination; HGNC; 31586; MIR21.
Sequence variations Heterozygous for ACVR2A p.Lys437fs*19 (c.1309_1310delAA) and p.Lys437fs*5 (c.1310delA) (from parent cell line).
Heterozygous for BRAF p.Val600Glu (c.1799T>A) (ClinVar=VCV000013961) (from parent cell line).
PIK3CA p.His1047Arg (c.3140A>G) (ClinVar=VCV000013652) (from parent cell line).
Heterozygous for TGFBR2 p.Lys128Serfs*35 (c.383delA) and p.Leu452Pro (c.1355T>C) (from parent cell line).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0504 (RKO)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Web pages https://www.horizondiscovery.com/human-mir21-rko-cell-line-hd-r05-013

PubMed=19826040; DOI=10.1158/0008-5472.CAN-09-1996
Wang P., Zou F., Zhang X., Li H., Dulak A., Tomko R.J. Jr., Lazo J.S., Wang Z., Zhang L., Yu J.
microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells.
Cancer Res. 69:8157-8165(2009)

Other Wikidata; Q54950553
Entry history
Entry creation01-Dec-2016
Last entry update02-Jul-2020
Version number5