ID   RKO MIR21(-/-)
AC   CVCL_HE23
SY   MIR21 (-/-) RKO; RKO miR-21 KO
DR   cancercelllines; CVCL_HE23
DR   Horizon_Discovery; HD+R05-013
DR   Wikidata; Q54950553
RX   PubMed=19826040;
CC   Knockout cell: Method=Homologous recombination; HGNC; 31586; MIR21.
CC   Sequence variation: Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11773; TGFBR2; Simple; p.Leu452Pro (c.1355T>C); ClinVar=VCV000930524; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4910; Colon carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0504 ! RKO
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 01-12-16; Last updated: 05-10-23; Version: 10
//
RX   PubMed=19826040; DOI=10.1158/0008-5472.CAN-09-1996;
RA   Wang P., Zou F.-D., Zhang X.-D., Li H., Dulak A.M., Tomko R.J. Jr.,
RA   Lazo J.S., Wang Z.-H., Zhang L., Yu J.;
RT   "microRNA-21 negatively regulates Cdc25A and cell cycle progression in
RT   colon cancer cells.";
RL   Cancer Res. 69:8157-8165(2009).
//