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Cellosaurus RKO SLC2A1(-/-) (CVCL_HE24)

[Text version]

Cell line name RKO SLC2A1(-/-)
Synonyms GLUT1 (-/-) RKO
Accession CVCL_HE24
Resource Identification Initiative To cite this cell line use: RKO SLC2A1(-/-) (RRID:CVCL_HE24)
Comments Knockout cell: Method=Homologous recombination; HGNC; 11005; SLC2A1.
Sequence variations Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11773; TGFBR2; Simple; p.Leu452Pro (c.1355T>C); ClinVar=VCV000930524; Zygosity=Heterozygous (from parent cell line).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0504 (RKO)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=19661383; DOI=10.1126/science.1174229
Yun J., Rago C., Cheong I., Pagliarini R., Angenendt P., Rajagopalan H., Schmidt K., Willson J.K.V., Markowitz S.D., Zhou S., Diaz L.A. Jr., Velculescu V.E., Lengauer C., Kinzler K.W., Vogelstein B., Papadopoulos N.
Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells.
Science 325:1555-1559(2009)

Cross-references
Cell line collections Horizon_Discovery; HD+R05-011
Other Wikidata; Q54950554
Entry history
Entry creation01-Dec-2016
Last entry update20-May-2021
Version number8