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Cellosaurus RKO TP53(-/-) (CVCL_HE25)

Cell line name RKO TP53(-/-)
Synonyms TP53 (-/-) RKO
Accession CVCL_HE25
Resource Identification Initiative To cite this cell line use: RKO TP53(-/-) (RRID:CVCL_HE25)
Comments Knockout cell: Method=Recombinant Adeno-Associated Virus; HGNC; 11998; TP53.
Sequence variations Heterozygous for ACVR2A p.Lys437fs*19 (c.1309_1310delAA) and p.Lys437fs*5 (c.1310delA) (from parent cell line).
Heterozygous for BRAF p.Val600Glu (c.1799T>A) (from parent cell line).
PIK3CA p.His1047Arg (c.3140A>G) (from parent cell line).
Heterozygous for TGFBR2 p.Lys128Serfs*35 (c.383delA) and p.Leu452Pro (c.1355T>C) (from parent cell line).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0504 (RKO)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Web pages https://www.horizondiscovery.com/human-tp53-rko-cell-line-hd-106-002
Publications

PubMed=19225112; DOI=10.1073/pnas.0813333106
Sur S., Pagliarini R., Bunz F., Rago C., Diaz L.A. Jr., Kinzler K.W., Vogelstein B., Papadopoulos N.
A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53.
Proc. Natl. Acad. Sci. U.S.A. 106:3964-3969(2009)

Cross-references
Other Wikidata; Q54950556