Cell line name |
RKO TP53(-/-) |
Synonyms |
TP53 (-/-) RKO |
Accession |
CVCL_HE25 |
Resource Identification Initiative |
To cite this cell line use: RKO TP53(-/-) (RRID:CVCL_HE25) |
Comments |
Knockout cell: Method=Recombinant Adeno-Associated Virus; HGNC; 11998; TP53. Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
Sequence variations |
- Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11773; TGFBR2; Simple; p.Leu452Pro (c.1355T>C); ClinVar=VCV000930524; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Colon carcinoma (NCIt: C4910) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0504 (RKO) |
Sex of cell |
Sex unspecified |
Age at sampling |
Age unspecified |
Category |
Cancer cell line |
Publications | PubMed=19225112; DOI=10.1073/pnas.0813333106 Sur S., Pagliarini R., Bunz F., Rago C., Diaz L.A. Jr., Kinzler K.W., Vogelstein B., Papadopoulos N. A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53. Proc. Natl. Acad. Sci. U.S.A. 106:3964-3969(2009) |
Cross-references |
Cell line collections (Providers) |
Horizon_Discovery; HD+106-002
|
Cell line databases/resources |
cancercelllines; CVCL_HE25
|
Encyclopedic resources |
Wikidata; Q54950556
|
Entry history |
Entry creation | 01-Dec-2016 |
Last entry update | 05-Oct-2023 |
Version number | 10 |
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