ID   RKO TP53(-/-)
AC   CVCL_HE25
SY   TP53 (-/-) RKO
DR   cancercelllines; CVCL_HE25
DR   Horizon_Discovery; HD+106-002
DR   Wikidata; Q54950556
RX   PubMed=19225112;
CC   Knockout cell: Method=Recombinant Adeno-Associated Virus; HGNC; 11998; TP53.
CC   Sequence variation: Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11773; TGFBR2; Simple; p.Leu452Pro (c.1355T>C); ClinVar=VCV000930524; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4910; Colon carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0504 ! RKO
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 01-12-16; Last updated: 05-10-23; Version: 10
//
RX   PubMed=19225112; DOI=10.1073/pnas.0813333106;
RA   Sur S., Pagliarini R., Bunz F., Rago C., Diaz L.A. Jr., Kinzler K.W.,
RA   Vogelstein B., Papadopoulos N.;
RT   "A panel of isogenic human cancer cells suggests a therapeutic
RT   approach for cancers with inactivated p53.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:3964-3969(2009).
//