ID   SW48 TP53(+/-)
AC   CVCL_HE26
SY   TP53 (+/-) SW48
DR   cancercelllines; CVCL_HE26
DR   Horizon_Discovery; HD+R06-001
DR   Wikidata; Q54971153
RX   PubMed=19225112;
CC   Population: Caucasian.
CC   Knockout cell: Method=Recombinant Adeno-Associated Virus; HGNC; 11998; TP53 (Note=1 of 2 alleles).
CC   Sequence variation: Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Arg2714Cys (c.8140C>T); ClinVar=VCV000231255; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 914; B2M; Simple; p.Ser14fs*29 (c.41_44delCTCT); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 914; B2M; Simple; p.Glu67fs (c.200delA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser33Tyr (c.98C>A); ClinVar=VCV000017577; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1724 ! SW48
SX   Female
AG   83Y
CA   Cancer cell line
DT   Created: 01-12-16; Last updated: 30-01-24; Version: 13
//
RX   PubMed=19225112; DOI=10.1073/pnas.0813333106;
RA   Sur S., Pagliarini R., Bunz F., Rago C., Diaz L.A. Jr., Kinzler K.W.,
RA   Vogelstein B., Papadopoulos N.;
RT   "A panel of isogenic human cancer cells suggests a therapeutic
RT   approach for cancers with inactivated p53.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:3964-3969(2009).
//