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Cellosaurus SW48 TP53(-/-) (CVCL_HE27)

Cell line name SW48 TP53(-/-)
Synonyms TP53 (-/-) SW48
Accession CVCL_HE27
Resource Identification Initiative To cite this cell line use: SW48 TP53(-/-) (RRID:CVCL_HE27)
Comments Knockout cell: Method=Recombinant Adeno-Associated Virus; HGNC; 11998; TP53.
Sequence variations Homozygous for ACVR2A p.Lys437fs*5 (c.1310delA) (from parent cell line).
APC p.Arg2714Cys (c.8140C>T) (from parent cell line).
Heterozygous for CTNNB1 p.Ser33Tyr (c.98C>A) (from parent cell line).
Homozygous for TGFBR2 p.Lys128Serfs*35 (c.383delA) (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1724 (SW48)
Sex of cell Female
Age at sampling 83Y
Category Cancer cell line
Web pages https://www.horizondiscovery.com/human-tp53-sw48-cell-line-hd-103-004
Publications

PubMed=19225112; DOI=10.1073/pnas.0813333106
Sur S., Pagliarini R., Bunz F., Rago C., Diaz L.A. Jr., Kinzler K.W., Vogelstein B., Papadopoulos N.
A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53.
Proc. Natl. Acad. Sci. U.S.A. 106:3964-3969(2009)

Cross-references
Other Wikidata; Q54971154