ID   CEM-R6
AC   CVCL_HF38
DR   cancercelllines; CVCL_HF38
DR   Wikidata; Q54809253
RX   PubMed=7812967;
CC   Population: Caucasian.
CC   Characteristics: Glucocorticoids resistant.
CC   Sequence variation: Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7978; NR3C1; Simple; p.Leu753Phe (c.2259A>T); ClinVar=VCV000016149; Zygosity=Heterozygous (PubMed=7812967).
CC   Sequence variation: Mutation; HGNC; 7978; NR3C1; Unexplicit; A>G mutation in the 3'-splice junction of intron G; Zygosity=Heterozygous (PubMed=7812967).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0207 ! CCRF-CEM
SX   Female
AG   3Y11M
CA   Cancer cell line
DT   Created: 01-12-16; Last updated: 05-10-23; Version: 17
//
RX   PubMed=7812967;
RA   Strasser-Wozak E.M.C., Hattmannstorfer R., Hala M., Hartmann B.L.,
RA   Fiegl M., Geley S., Kofler R.;
RT   "Splice site mutation in the glucocorticoid receptor gene causes
RT   resistance to glucocorticoid-induced apoptosis in a human acute
RT   leukemic cell line.";
RL   Cancer Res. 55:348-353(1995).
//