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Cellosaurus SKOV3/TR (CVCL_HF69)

Cell line name SKOV3/TR
Accession CVCL_HF69
Resource Identification Initiative To cite this cell line use: SKOV3/TR (RRID:CVCL_HF69)
Comments Selected for resistance to: ChEBI; CHEBI:45863; Paclitaxel (Taxol).
Sequence variations Heterozygous for APC p.Thr1556fs*9 (c.4666delA) (from parent cell line).
Heterozygous for PIK3CA p.His1047Arg (c.3140A>G) (from parent cell line).
Homozygous for TP53 p.Ser90fs*33 (c.267delC) (from parent cell line).
Disease Ovarian serous cystadenocarcinoma (NCIt: C7978)
Derived from metastatic site: Ascites.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0532 (SK-OV-3)
Sex of cell Female
Age at sampling 64Y
Category Cancer cell line

PubMed=25815442; DOI=10.3892/mmr.2015.3542
Lee C.
Overexpression of Tyro3 receptor tyrosine kinase leads to the acquisition of taxol resistance in ovarian cancer cells.
Mol. Med. Rep. 12:1485-1492(2015)

Other Wikidata; Q54954771