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Cellosaurus Tet2 (CVCL_HF70)

[Text version]
Cell line name Tet2
Synonyms TET2; SHEP-2; SHEP2
Accession CVCL_HF70
Resource Identification Initiative To cite this cell line use: Tet2 (RRID:CVCL_HF70)
Comments Population: Caucasian.
Transfected with: UniProtKB; P04483; Escherichia coli Tn10 tetR.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Mutation; HGNC; 427; ALK; Simple; p.Phe1174Leu (c.3522C>A); ClinVar=VCV000217852; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2A38 (SHEP-SF)
Sex of cell Female
Age at sampling 4Y
Category Cancer cell line
Publications

PubMed=8761302
Lutz W., Stohr M., Schurmann J., Wenzel A., Lohr A., Schwab M.
Conditional expression of N-myc in human neuroblastoma cells increases expression of alpha-prothymosin and ornithine decarboxylase and accelerates progression into S-phase early after mitogenic stimulation of quiescent cells.
Oncogene 13:803-812(1996)

PubMed=17506115; DOI=10.1002/nbm.1181
Peet A.C., McConville C.M., Wilson M.P., Levine B.A., Reed M., Dyer S.A., Edwards E.C., Strachan M.C., McMullan D.J., Wilkes T.M., Grundy R.G.
1H MRS identifies specific metabolite profiles associated with MYCN-amplified and non-amplified tumour subtypes of neuroblastoma cell lines.
NMR Biomed. 20:692-700(2007)

PubMed=22213050; DOI=10.1002/ijc.27415
Gawecka J.E., Geerts D., Koster J., Caliva M.J., Sulzmaier F.J., Opoku-Ansah J., Wada R.K., Bachmann A.S., Ramos J.W.
PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma.
Int. J. Cancer 131:1556-1568(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_HF70
Encyclopedic resources Wikidata; Q54972194
Gene expression databases GEO; GSM692875
Entry history
Entry creation01-Dec-2016
Last entry update05-Oct-2023
Version number11