| Cell line name | HCT 116 AXL KO Tet-inducible |
|---|---|
| Accession | CVCL_HG04 |
| Resource Identification Initiative | To cite this cell line use: HCT 116 AXL KO Tet-inducible (RRID:CVCL_HG04) |
| Comments | Knockout cell: Method=shRNA knockdown; HGNC; 905; AXL. Derived from sampling site: Colon. |
| Sequence variations | Homozygous for ACVR2A p.Lys437Argfs*5 (c.1310delA) (dbSNP=rs764719749) (from parent cell line).Heterozygous for BRCA2 p.Ile2675Aspfs*6 (c.8021dupA) (c.8021_8022insA) (ClinVar=VCV000267050) (from parent cell line).Heterozygous for CDKN2A p.Arg24fs*20 (c.68_69insG) and p.Glu74fs*15 (c.220delG) (from parent cell line).Heterozygous for CTNNB1 p.Ser45del (c.133_135delTCT) (ClinVar=VCV000017576) (from parent cell line).Heterozygous for KRAS p.Gly13Asp (c.38G>A) (ClinVar=VCV000012580) (from parent cell line).Heterozygous for PIK3CA p.His1047Arg (c.3140A>G) (ClinVar=VCV000013652) (from parent cell line).Homozygous for TGFBR2 p.Lys128Serfs*35 (c.383delA) (ClinVar=VCV000477546) (from parent cell line). |
| Disease | Colon carcinoma (NCIt: C4910) |
| Species of origin | Homo sapiens (Human)
(NCBI Taxonomy: 9606)
|
| Hierarchy | Parent: CVCL_0291 (HCT 116) |
| Sex of cell | Male |
| Age at sampling | 48Y |
| Category | Cancer cell line |
| Publications | PubMed=24170546; DOI=10.1158/1078-0432.CCR-13-1354 |
| Cross-references | |
| Cell line collections | Ximbio; 153206 |
| Other | Wikidata; Q54881912 |
| Entry history | |
| Entry creation | 01-Dec-2016 |
| Last entry update | 29-Oct-2020 |
| Version number | 7 |