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Cellosaurus HCT 116 AXL KO Tet-inducible (CVCL_HG04)

[Text version]

Cell line name HCT 116 AXL KO Tet-inducible
Accession CVCL_HG04
Resource Identification Initiative To cite this cell line use: HCT 116 AXL KO Tet-inducible (RRID:CVCL_HG04)
Comments Knockout cell: Method=shRNA knockdown; HGNC; 905; AXL.
Derived from sampling site: Colon.
Sequence variations Homozygous for ACVR2A p.Lys437Argfs*5 (c.1310delA) (dbSNP=rs764719749) (from parent cell line).
Heterozygous for BRCA2 p.Ile2675Aspfs*6 (c.8021dupA) (c.8021_8022insA) (ClinVar=VCV000267050) (from parent cell line).
Heterozygous for CDKN2A p.Arg24fs*20 (c.68_69insG) and p.Glu74fs*15 (c.220delG) (from parent cell line).
Heterozygous for CTNNB1 p.Ser45del (c.133_135delTCT) (ClinVar=VCV000017576) (from parent cell line).
Heterozygous for KRAS p.Gly13Asp (c.38G>A) (ClinVar=VCV000012580) (from parent cell line).
Heterozygous for PIK3CA p.His1047Arg (c.3140A>G) (ClinVar=VCV000013652) (from parent cell line).
Homozygous for TGFBR2 p.Lys128Serfs*35 (c.383delA) (ClinVar=VCV000477546) (from parent cell line).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0291 (HCT 116)
Sex of cell Male
Age at sampling 48Y
Category Cancer cell line
Publications

PubMed=24170546; DOI=10.1158/1078-0432.CCR-13-1354
Dunne P.D., McArt D.G., Blayney J.K., Kalimutho M., Greer S., Wang T., Srivastava S., Ong C.W., Arthur K., Loughrey M., Redmond K.L., Longley D.B., Salto-Tellez M., Johnston P.G., Van Schaeybroeck S.
AXL is a key regulator of inherent and chemotherapy-induced invasion and predicts a poor clinical outcome in early-stage colon cancer.
Clin. Cancer Res. 20:164-175(2014)

Cross-references
Cell line collections Ximbio; 153206
Other Wikidata; Q54881912
Entry history
Entry creation01-Dec-2016
Last entry update29-Oct-2020
Version number7