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Cellosaurus HCT 116-I6 (CVCL_HG06)

[Text version]

Cell line name HCT 116-I6
Synonyms HCT116-I6
Accession CVCL_HG06
Resource Identification Initiative To cite this cell line use: HCT 116-I6 (RRID:CVCL_HG06)
Comments Characteristics: Demonstrates a 4x and 20x increase in migration and invasion rate respectively compared to HCT 116.
Derived from sampling site: Colon.
Sequence variations Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; 1101; BRCA2; Simple; p.Ile2675Aspfs*6 (c.8021dupA) (c.8021_8022insA); ClinVar=VCV000267050; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg24Serfs*20 (c.68dupG) (c.68_69insG) (p.G23fs); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 3373; EP300; Simple; p.Met1470Cysfs*22 (c.4408delA); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 3373; EP300; Simple; p.Asn1700Thrfs*9 (c.5099delA); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0291 (HCT 116)
Sex of cell Male
Age at sampling 48Y
Category Cancer cell line
Publications

PubMed=24170546; DOI=10.1158/1078-0432.CCR-13-1354
Dunne P.D., McArt D.G., Blayney J.K., Kalimutho M., Greer S., Wang T.-T., Srivastava S., Ong C.W., Arthur K., Loughrey M., Redmond K.L., Longley D.B., Salto-Tellez M., Johnston P.G., van Schaeybroeck S.
AXL is a key regulator of inherent and chemotherapy-induced invasion and predicts a poor clinical outcome in early-stage colon cancer.
Clin. Cancer Res. 20:164-175(2014)

Cross-references
Cell line collections Ximbio; 153208
Other Wikidata; Q54881994
Entry history
Entry creation01-Dec-2016
Last entry update20-May-2021
Version number9