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Cellosaurus S_M6R1 (CVCL_HG09)

[Text version]

Cell line name S_M6R1
Accession CVCL_HG09
Resource Identification Initiative To cite this cell line use: S_M6R1 (RRID:CVCL_HG09)
Comments Selected for resistance to: ChEBI; CHEBI:134602; MI-63.
Derived from sampling site: Bone.
Sequence variations Hemizygous for CDKN2A deletion (from parent cell line).
Heterozygous for KRAS p.Gln61His (c.183A>T) (ClinVar=VCV000045117) (from parent cell line).
Heterozygous for NRAS p.Gln61Lys (c.181C>A) (ClinVar=VCV000073058) (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1697 (SJSA-1)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
Publications

PubMed=27323823; DOI=10.18632/oncotarget.10073
Drummond C.J., Esfandiari A., Liu J., Lu X., Hutton C., Jackson J., Bennaceur K., Xu Q., Makimanejavali A.R., Del Bello F., Piergentili A., Newell D.R., Hardcastle I.R., Griffin R.J., Lunec J.
TP53 mutant MDM2-amplified cell lines selected for resistance to MDM2-p53 binding antagonists retain sensitivity to ionizing radiation.
Oncotarget 7:46203-46218(2016)

Cross-references
Cell line collections Ximbio; 152839
Other Wikidata; Q54951555
Entry history
Entry creation01-Dec-2016
Last entry updated02-Jul-2020
Version number8