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Cellosaurus S_M6R1 (CVCL_HG09)

[Text version]

Cell line name S_M6R1
Accession CVCL_HG09
Resource Identification Initiative To cite this cell line use: S_M6R1 (RRID:CVCL_HG09)
Comments Population: African American.
Selected for resistance to: ChEBI; CHEBI:134602; MI-63.
Derived from sampling site: Bone; femur.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gln61His (c.183A>T); ClinVar=VCV000045117; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1697 (SJSA-1)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
Publications

PubMed=27323823; DOI=10.18632/oncotarget.10073
Drummond C.J., Esfandiari A., Liu J.-F., Lu X.-H., Hutton C., Jackson J., Bennaceur K., Xu Q., Makimanejavali A.R., Del Bello F., Piergentili A., Newell D.R., Hardcastle I.R., Griffin R.J., Lunec J.
TP53 mutant MDM2-amplified cell lines selected for resistance to MDM2-p53 binding antagonists retain sensitivity to ionizing radiation.
Oncotarget 7:46203-46218(2016)

Cross-references
Cell line collections CancerTools; 152839
Ximbio; 152839
Encyclopedic resources Wikidata; Q54951555
Entry history
Entry creation01-Dec-2016
Last entry update23-Jun-2022
Version number12