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Cellosaurus S_N40R2 (CVCL_HG10)

[Text version]

Cell line name S_N40R2
Accession CVCL_HG10
Resource Identification Initiative To cite this cell line use: S_N40R2 (RRID:CVCL_HG10)
Comments Selected for resistance to: ChEBI; CHEBI:46742; Nutlin-3.
Derived from sampling site: Bone.
Sequence variations Hemizygous for CDKN2A deletion (from parent cell line).
Heterozygous for KRAS p.Gln61His (c.183A>T) (ClinVar=VCV000045117) (from parent cell line).
Heterozygous for NRAS p.Gln61Lys (c.181C>A) (ClinVar=VCV000073058) (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1697 (SJSA-1)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
STR profile Source(s): ECACC

Markers:
AmelogeninX,Y
CSF1PO7.3,10.1
D3S135816,17
D5S81812
D7S8209,11
D8S117913,15
D13S31712
D16S5399,10
D18S5115,17
D21S1128,33.2
FGA22,23
Penta D2.2,10
Penta E11,14
TH017,9
TPOX8,9
vWA19

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Publications

PubMed=27323823; DOI=10.18632/oncotarget.10073
Drummond C.J., Esfandiari A., Liu J., Lu X., Hutton C., Jackson J., Bennaceur K., Xu Q., Makimanejavali A.R., Del Bello F., Piergentili A., Newell D.R., Hardcastle I.R., Griffin R.J., Lunec J.
TP53 mutant MDM2-amplified cell lines selected for resistance to MDM2-p53 binding antagonists retain sensitivity to ionizing radiation.
Oncotarget 7:46203-46218(2016)

Cross-references
Cell line collections ECACC; 17011210
Ximbio; 152838
Other Wikidata; Q54951556
Entry history
Entry creation01-Dec-2016
Last entry updated02-Jul-2020
Version number7