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Cellosaurus T47D-ST3 (CVCL_HG15)

[Text version]

Cell line name T47D-ST3
Synonyms T47D 3STMYC
Accession CVCL_HG15
Resource Identification Initiative To cite this cell line use: T47D-ST3 (RRID:CVCL_HG15)
Comments Transfected with: HGNC; 10862; ST3GAL1.
Sequence variations Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Leu194Phe (c.580C>T); ClinVar=VCV000127817; Zygosity=Homozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0553 (T-47D)
CVCL_HG17 (T47D-ST3-STn)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line

PubMed=9182658; DOI=10.1083/jcb.137.6.1229
Whitehouse C., Burchell J.M., Gschmeissner S., Brockhausen I., Lloyd K.O., Taylor-Papadimitriou J.
A transfected sialyltransferase that is elevated in breast cancer and localizes to the medial/trans-Golgi apparatus inhibits the development of core-2-based O-glycans.
J. Cell Biol. 137:1229-1241(1997)

PubMed=16319059; DOI=10.1074/jbc.M511826200
Sewell R., Backstrom M., Dalziel M., Gschmeissner S., Karlsson H., Noll T., Gatgens J., Clausen H., Hansson G.C., Burchell J.M., Taylor-Papadimitriou J.
The ST6GalNAc-I sialyltransferase localizes throughout the Golgi and is responsible for the synthesis of the tumor-associated sialyl-Tn O-glycan in human breast cancer.
J. Biol. Chem. 281:3586-3594(2006)

Other Wikidata; Q54971564
Entry history
Entry creation01-Dec-2016
Last entry update20-May-2021
Version number8