ID   T47D-ST3
AC   CVCL_HG15
SY   T47D 3STMYC
DR   cancercelllines; CVCL_HG15
DR   Wikidata; Q54971564
RX   PubMed=9182658;
RX   PubMed=16319059;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Leu194Phe (c.580C>T); ClinVar=VCV000127817; Zygosity=Homozygous (from parent cell line).
CC   Transfected with: HGNC; 10862; ST3GAL1.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0553 ! T-47D
SX   Female
AG   54Y
CA   Cancer cell line
DT   Created: 01-12-16; Last updated: 05-10-23; Version: 11
//
RX   PubMed=9182658; DOI=10.1083/jcb.137.6.1229;
RA   Whitehouse C., Burchell J.M., Gschmeissner S., Brockhausen I.,
RA   Lloyd K.O., Taylor-Papadimitriou J.;
RT   "A transfected sialyltransferase that is elevated in breast cancer and
RT   localizes to the medial/trans-Golgi apparatus inhibits the development
RT   of core-2-based O-glycans.";
RL   J. Cell Biol. 137:1229-1241(1997).
//
RX   PubMed=16319059; DOI=10.1074/jbc.M511826200;
RA   Sewell R., Backstrom M., Dalziel M., Gschmeissner S., Karlsson H.,
RA   Noll T., Gatgens J., Clausen H., Hansson G.C., Burchell J.M.,
RA   Taylor-Papadimitriou J.;
RT   "The ST6GalNAc-I sialyltransferase localizes throughout the Golgi and
RT   is responsible for the synthesis of the tumor-associated sialyl-Tn
RT   O-glycan in human breast cancer.";
RL   J. Biol. Chem. 281:3586-3594(2006).
//