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Cellosaurus CFBE41o- (CVCL_HL93)

[Text version]
Cell line name CFBE41o-
Synonyms CFBE41o(-); CF41o; CFBE
Accession CVCL_HL93
Resource Identification Initiative To cite this cell line use: CFBE41o- (RRID:CVCL_HL93)
Comments Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) [Note=pSVori-].
Omics: Proteome analysis by 2D-DE/MS.
Derived from site: In situ; Lung, bronchus, epithelium; UBERON=UBERON_0002031.
Cell type: Epithelial cell of bronchus; CL=CL_0002328.
Sequence variations
  • Mutation; HGNC; 1884; CFTR; Simple; p.Phe508del (c.1521_1523delCTT); ClinVar=VCV000007105; Zygosity=Homozygous (PubMed=15463957).
Disease Cystic fibrosis (NCIt: C2975)
Cystic fibrosis (ORDO: Orphanet_586)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_WZ18 (CF8Flp)CVCL_VP35 (CFBE41o- 4.7 DeltaF508-CFTR)CVCL_VP34 (CFBE41o- 4.7 WT-CFTR)
CVCL_VP37 (CFBE41o- 6.2 DeltaF508-CFTR)CVCL_VP36 (CFBE41o- 6.2 WT-CFTR)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Transformed cell line
STR profile Source(s): Millipore

Markers:
AmelogeninX
CSF1PO11
D3S135816,18
D5S81813
D7S8208,11
D8S117911,14
D13S3179,11
D16S53912
D18S5115,16
D21S1129,31.2
FGA22,24
Penta D11,12
Penta E12
TH019.3
TPOX8,9
vWA17

Run an STR similarity search on this cell line
Web pages http://www.dartmouth.edu/~cysfib/cell-lines.html
Publications

PubMed=9614386; DOI=10.1002/(SICI)1096-9896(199803)184:3<323::AID-PATH2>3.0.CO;2-2
Meng Q.-H., Springall D.R., Bishop A.E., Morgan K., Evans T.J., Habib S., Gruenert D.C., Gyi K.M., Hodson M.E., Yacoub M.H., Polak J.M.
Lack of inducible nitric oxide synthase in bronchial epithelium: a possible mechanism of susceptibility to infection in cystic fibrosis.
J. Pathol. 184:323-331(1998)

PubMed=12032687; DOI=10.1038/sj.gt.3301741
Bruscia E., Sangiuolo F., Sinibaldi P., Goncz K.K., Novelli G., Gruenert D.C.
Isolation of CF cell lines corrected at DeltaF508-CFTR locus by SFHR-mediated targeting.
Gene Ther. 9:683-685(2002)

PubMed=15463957; DOI=10.1016/j.jcf.2004.05.040
Gruenert D.C., Willems M., Cassiman J.-J., Frizzell R.A.
Established cell lines used in cystic fibrosis research.
J. Cyst. Fibros. 3:191-196(2004)

PubMed=16249874; DOI=10.1007/s00441-005-0062-7
Ehrhardt C., Collnot E.-M., Baldes C., Becker U., Laue M., Kim K.-J., Lehr C.-M.
Towards an in vitro model of cystic fibrosis small airway epithelium: characterisation of the human bronchial epithelial cell line CFBE41o-.
Cell Tissue Res. 323:405-415(2006)

PubMed=28970102; DOI=10.1016/j.jprot.2017.09.013
Puglia M., Landi C., Gagliardi A., Breslin L., Armini A., Brunetti J., Pini A., Bianchi L., Bini L.
The proteome speciation of an immortalized cystic fibrosis cell line: new perspectives on the pathophysiology of the disease.
J. Proteomics 170:28-42(2018)

Cross-references
Cell line collections (Providers) Millipore; SCC151
Cell line databases/resources Lonza; 1158
Encyclopedic resources Wikidata; Q54811428
Gene expression databases GEO; GSM2126999
GEO; GSM2127001
GEO; GSM2127003
Proteomic databases PRIDE; PXD006933
Entry history
Entry creation01-Dec-2016
Last entry update05-Oct-2023
Version number14