ID   CFBE41o-
AC   CVCL_HL93
SY   CFBE41o(-); CF41o; CFBE
DR   GEO; GSM2126999
DR   GEO; GSM2127001
DR   GEO; GSM2127003
DR   Lonza; 1158
DR   Millipore; SCC151
DR   PRIDE; PXD006933
DR   Wikidata; Q54811428
RX   PubMed=9614386;
RX   PubMed=12032687;
RX   PubMed=15463957;
RX   PubMed=16249874;
RX   PubMed=28970102;
WW   http://www.dartmouth.edu/~cysfib/cell-lines.html
CC   Sequence variation: Mutation; HGNC; 1884; CFTR; Simple; p.Phe508del (c.1521_1523delCTT); ClinVar=VCV000007105; Zygosity=Homozygous (PubMed=15463957).
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) [Note=pSVori-].
CC   Omics: Proteome analysis by 2D-DE/MS.
CC   Derived from site: In situ; Lung, bronchus, epithelium; UBERON=UBERON_0002031.
CC   Cell type: Epithelial cell of bronchus; CL=CL_0002328.
ST   Source(s): Millipore
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 9,11
ST   D16S539: 12
ST   D18S51: 15,16
ST   D21S11: 29,31.2
ST   D3S1358: 16,18
ST   D5S818: 13
ST   D7S820: 8,11
ST   D8S1179: 11,14
ST   FGA: 22,24
ST   Penta D: 11,12
ST   Penta E: 12
ST   TH01: 9.3
ST   TPOX: 8,9
ST   vWA: 17
DI   NCIt; C2975; Cystic fibrosis
DI   ORDO; Orphanet_586; Cystic fibrosis
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Transformed cell line
DT   Created: 01-12-16; Last updated: 05-10-23; Version: 14
//
RX   PubMed=9614386; DOI=10.1002/(SICI)1096-9896(199803)184:3<323::AID-PATH2>3.0.CO;2-2;
RA   Meng Q.-H., Springall D.R., Bishop A.E., Morgan K., Evans T.J.,
RA   Habib S., Gruenert D.C., Gyi K.M., Hodson M.E., Yacoub M.H.,
RA   Polak J.M.;
RT   "Lack of inducible nitric oxide synthase in bronchial epithelium: a
RT   possible mechanism of susceptibility to infection in cystic
RT   fibrosis.";
RL   J. Pathol. 184:323-331(1998).
//
RX   PubMed=12032687; DOI=10.1038/sj.gt.3301741;
RA   Bruscia E., Sangiuolo F., Sinibaldi P., Goncz K.K., Novelli G.,
RA   Gruenert D.C.;
RT   "Isolation of CF cell lines corrected at DeltaF508-CFTR locus by
RT   SFHR-mediated targeting.";
RL   Gene Ther. 9:683-685(2002).
//
RX   PubMed=15463957; DOI=10.1016/j.jcf.2004.05.040;
RA   Gruenert D.C., Willems M., Cassiman J.-J., Frizzell R.A.;
RT   "Established cell lines used in cystic fibrosis research.";
RL   J. Cyst. Fibros. 3:191-196(2004).
//
RX   PubMed=16249874; DOI=10.1007/s00441-005-0062-7;
RA   Ehrhardt C., Collnot E.-M., Baldes C., Becker U., Laue M., Kim K.-J.,
RA   Lehr C.-M.;
RT   "Towards an in vitro model of cystic fibrosis small airway epithelium:
RT   characterisation of the human bronchial epithelial cell line
RT   CFBE41o-.";
RL   Cell Tissue Res. 323:405-415(2006).
//
RX   PubMed=28970102; DOI=10.1016/j.jprot.2017.09.013;
RA   Puglia M., Landi C., Gagliardi A., Breslin L., Armini A., Brunetti J.,
RA   Pini A., Bianchi L., Bini L.;
RT   "The proteome speciation of an immortalized cystic fibrosis cell line:
RT   new perspectives on the pathophysiology of the disease.";
RL   J. Proteomics 170:28-42(2018).
//