ID   MDN
AC   CVCL_HX07
DR   ArrayExpress; E-TABM-1088
DR   cancercelllines; CVCL_HX07
DR   Cosmic; 2809778
DR   IARC_TP53; 28508
DR   Wikidata; Q54904815
RX   PubMed=10583232;
RX   PubMed=16956823;
RX   PubMed=21173094;
RX   PubMed=30545397;
WW   https://www.keatslab.org/myeloma-cell-lines/hmcl-characteristics
CC   Characteristics: IL6 dependent.
CC   HLA typing: A*01,02:09; B*44,51; C*04,14 (Direct_author_submission).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000013901; Zygosity=Unspecified (PubMed=21173094).
CC   Omics: Deep exome analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Miscellaneous: HLA typing from personal communication of Pellat-Deceunynck C.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C3242; Plasma cell myeloma
DI   ORDO; Orphanet_29073; Multiple myeloma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 01-12-16; Last updated: 05-10-23; Version: 13
//
RX   PubMed=10583232; DOI=10.1046/j.1365-2141.1999.01705.x;
RA   Puthier D., Derenne S., Barille S., Moreau P., Harousseau J.-L.,
RA   Bataille R., Amiot M.;
RT   "Mcl-1 and Bcl-xL are co-regulated by IL-6 in human myeloma cells.";
RL   Br. J. Haematol. 107:392-395(1999).
//
RX   PubMed=16956823;
RA   Bataille R., Jego G., Robillard N., Barille-Nion S., Harousseau J.-L.,
RA   Moreau P., Amiot M., Pellat-Deceunynck C.;
RT   "The phenotype of normal, reactive and malignant plasma cells.
RT   Identification of 'many and multiple myelomas' and of new targets for
RT   myeloma therapy.";
RL   Haematologica 91:1234-1240(2006).
//
RX   PubMed=21173094; DOI=10.3324/haematol.2010.033456;
RA   Moreaux J., Klein B., Bataille R., Descamps G., Maiga S., Hose D.,
RA   Goldschmidt H., Jauch A., Reme T., Jourdan M., Amiot M.,
RA   Pellat-Deceunynck C.;
RT   "A high-risk signature for patients with multiple myeloma established
RT   from the molecular classification of human myeloma cell lines.";
RL   Haematologica 96:574-582(2011).
//
RX   PubMed=30545397; DOI=10.1186/s13045-018-0679-0;
RA   Tessoulin B., Moreau-Aubry A., Descamps G., Gomez-Bougie P., Maiga S.,
RA   Gaignard A., Chiron D., Menoret E., Le Gouill S., Moreau P., Amiot M.,
RA   Pellat-Deceunynck C.;
RT   "Whole-exon sequencing of human myeloma cell lines shows mutations
RT   related to myeloma patients at relapse with major hits in the DNA
RT   regulation and repair pathways.";
RL   J. Hematol. Oncol. 11:137.1-137.13(2018).
//