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Cellosaurus NAN-6 (CVCL_HX09)

[Text version]
Cell line name NAN-6
Synonyms NAN6
Accession CVCL_HX09
Resource Identification Initiative To cite this cell line use: NAN-6 (RRID:CVCL_HX09)
Comments Characteristics: Produces IgA kappa.
Characteristics: IL6 dependent.
Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray.
Miscellaneous: Age at sampling and HLA typing from personal communication of Pellat-Deceunynck C.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Unexplicit; Ex7-9del; Zygosity=Unspecified (PubMed=21173094).
HLA typing Source: Direct_author_submission
Class I
HLA-AA*03,30
HLA-BB*07,51
HLA-CC*07,12
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 52Y
Category Cancer cell line
Web pages https://www.keatslab.org/myeloma-cell-lines/hmcl-characteristics
Publications

PubMed=16956823
Bataille R., Jego G., Robillard N., Barille-Nion S., Harousseau J.-L., Moreau P., Amiot M., Pellat-Deceunynck C.
The phenotype of normal, reactive and malignant plasma cells Identification of 'many and multiple myelomas' and of new targets for myeloma therapy.
Haematologica 91:1234-1240(2006)

PubMed=21173094; DOI=10.3324/haematol.2010.033456
Moreaux J., Klein B., Bataille R., Descamps G., Maiga S., Hose D., Goldschmidt H., Jauch A., Reme T., Jourdan M., Amiot M., Pellat-Deceunynck C.
A high-risk signature for patients with multiple myeloma established from the molecular classification of human myeloma cell lines.
Haematologica 96:574-582(2011)

PubMed=30545397; DOI=10.1186/s13045-018-0679-0
Tessoulin B., Moreau-Aubry A., Descamps G., Gomez-Bougie P., Maiga S., Gaignard A., Chiron D., Menoret E., Le Gouill S., Moreau P., Amiot M., Pellat-Deceunynck C.
Whole-exon sequencing of human myeloma cell lines shows mutations related to myeloma patients at relapse with major hits in the DNA regulation and repair pathways.
J. Hematol. Oncol. 11:137.1-137.13(2018)

Cross-references
Encyclopedic resources Wikidata; Q54907479
Gene expression databases ArrayExpress; E-TABM-1088
Polymorphism and mutation databases Cosmic; 2809781
IARC_TP53; 28496
Entry history
Entry creation01-Dec-2016
Last entry update29-Jun-2023
Version number10