ID   XG-10
AC   CVCL_HX11
SY   XG10
DR   ArrayExpress; E-TABM-1088
DR   IARC_TP53; 28491
DR   Wikidata; Q54994695
RX   PubMed=10557056;
RX   PubMed=19718049;
RX   PubMed=21173094;
RX   PubMed=30545397;
WW   https://www.keatslab.org/myeloma-cell-lines/hmcl-characteristics
CC   Characteristics: IL6 dependent.
CC   HLA typing: A*01,24; B*14,51; C*08,14 (Direct_author_submission).
CC   Sequence variation: Has no TP53 mutation (PubMed=21173094).
CC   Omics: Deep exome analysis.
CC   Omics: Transcriptome analysis.
CC   Miscellaneous: HLA typing from personal communication of Pellat-Deceunynck C.
CC   Derived from sampling site: Ascites.
DI   NCIt; C3242; Plasma cell myeloma
DI   ORDO; Orphanet_29073; Multiple myeloma
OX   NCBI_TaxID=9606; ! Homo sapiens
SX   Female
CA   Cancer cell line
DT   Created: 01-12-16; Last updated: 12-03-20; Version: 5
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RX   PubMed=10557056; DOI=10.1038/sj.leu.2401563;
RA   Yoshida S., Nakazawa N., Iida S., Hayami Y., Sato S., Wakita A.,
RA   Shimizu S., Taniwaki M., Ueda R.;
RT   "Detection of MUM1/IRF4-IgH fusion in multiple myeloma.";
RL   Leukemia 13:1812-1816(1999).
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RX   PubMed=19718049; DOI=10.1038/onc.2009.257;
RA   Seckinger A., Meissner T., Moreaux J., Goldschmidt H., Fuhler G.M.,
RA   Benner A., Hundemer M., Reme T., Shaughnessy J.D. Jr., Barlogie B.,
RA   Bertsch U., Hillengass J., Ho A.D., Pantesco V., Jauch A., De Vos J.,
RA   Rossi J.F., Mohler T., Klein B., Hose D.;
RT   "Bone morphogenic protein 6: a member of a novel class of prognostic
RT   factors expressed by normal and malignant plasma cells inhibiting
RT   proliferation and angiogenesis.";
RL   Oncogene 28:3866-3879(2009).
//
RX   PubMed=21173094; DOI=10.3324/haematol.2010.033456;
RA   Moreaux J., Klein B., Bataille R., Descamps G., Maiga S., Hose D.,
RA   Goldschmidt H., Jauch A., Reme T., Jourdan M., Amiot M.,
RA   Pellat-Deceunynck C.;
RT   "A high-risk signature for patients with multiple myeloma established
RT   from the molecular classification of human myeloma cell lines.";
RL   Haematologica 96:574-582(2011).
//
RX   PubMed=30545397; DOI=10.1186/s13045-018-0679-0;
RA   Tessoulin B., Moreau-Aubry A., Descamps G., Gomez-Bougie P., Maiga S.,
RA   Gaignard A., Chiron D., Menoret E., Le Gouill S., Moreau P., Amiot M.,
RA   Pellat-Deceunynck C.;
RT   "Whole-exon sequencing of human myeloma cell lines shows mutations
RT   related to myeloma patients at relapse with major hits in the DNA
RT   regulation and repair pathways.";
RL   J. Hematol. Oncol. 11:137-137(2018).
//