ID   XG-11
AC   CVCL_HX12
SY   XG11
DR   ArrayExpress; E-TABM-1088
DR   cancercelllines; CVCL_HX12
DR   Cosmic; 2809775
DR   IARC_TP53; 28502
DR   Wikidata; Q54994696
RX   PubMed=19718049;
RX   PubMed=21173094;
RX   PubMed=30545397;
WW   https://www.keatslab.org/myeloma-cell-lines/hmcl-characteristics
CC   Characteristics: Produces Ig lambda.
CC   Characteristics: IL6 dependent.
CC   HLA typing: A*02,26; B*18,38; C*07,12 (Direct_author_submission).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Cys135Tyr (c.404G>A); ClinVar=VCV000141762; Zygosity=Unspecified (PubMed=21173094).
CC   Omics: Deep exome analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Miscellaneous: HLA typing from personal communication of Pellat-Deceunynck C.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C3242; Plasma cell myeloma
DI   ORDO; Orphanet_29073; Multiple myeloma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
CA   Cancer cell line
DT   Created: 01-12-16; Last updated: 05-10-23; Version: 12
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RX   PubMed=19718049; DOI=10.1038/onc.2009.257;
RA   Seckinger A., Meissner T., Moreaux J., Goldschmidt H., Fuhler G.M.,
RA   Benner A., Hundemer M., Reme T., Shaughnessy J.D. Jr., Barlogie B.,
RA   Bertsch U., Hillengass J., Ho A.D., Pantesco V., Jauch A., De Vos J.,
RA   Rossi J.F., Mohler T., Klein B., Hose D.;
RT   "Bone morphogenic protein 6: a member of a novel class of prognostic
RT   factors expressed by normal and malignant plasma cells inhibiting
RT   proliferation and angiogenesis.";
RL   Oncogene 28:3866-3879(2009).
//
RX   PubMed=21173094; DOI=10.3324/haematol.2010.033456;
RA   Moreaux J., Klein B., Bataille R., Descamps G., Maiga S., Hose D.,
RA   Goldschmidt H., Jauch A., Reme T., Jourdan M., Amiot M.,
RA   Pellat-Deceunynck C.;
RT   "A high-risk signature for patients with multiple myeloma established
RT   from the molecular classification of human myeloma cell lines.";
RL   Haematologica 96:574-582(2011).
//
RX   PubMed=30545397; DOI=10.1186/s13045-018-0679-0;
RA   Tessoulin B., Moreau-Aubry A., Descamps G., Gomez-Bougie P., Maiga S.,
RA   Gaignard A., Chiron D., Menoret E., Le Gouill S., Moreau P., Amiot M.,
RA   Pellat-Deceunynck C.;
RT   "Whole-exon sequencing of human myeloma cell lines shows mutations
RT   related to myeloma patients at relapse with major hits in the DNA
RT   regulation and repair pathways.";
RL   J. Hematol. Oncol. 11:137.1-137.13(2018).
//