ID   XG-16
AC   CVCL_HX16
SY   XG16
DR   ArrayExpress; E-TABM-1088
DR   IARC_TP53; 28499
DR   Wikidata; Q54994701
RX   PubMed=21173094;
RX   PubMed=30545397;
WW   https://www.keatslab.org/myeloma-cell-lines/hmcl-characteristics
CC   Characteristics: Produces Ig kappa.
CC   Characteristics: IL6 dependent.
CC   HLA typing: A*02,29; B*40,49; C*02,07 (Direct_author_submission).
CC   Sequence variation: NRAS p.Gln61His (c.183A>C) (PubMed=21173094).
CC   Sequence variation: TP53 p.Tyr220Cys (c.659A>G) (PubMed=21173094).
CC   Omics: Deep exome analysis.
CC   Omics: Transcriptome analysis.
CC   Miscellaneous: HLA typing from personal communication of Pellat-Deceunynck C.
CC   Derived from sampling site: Peripheral blood.
DI   NCIt; C3242; Plasma cell myeloma
DI   ORDO; Orphanet_29073; Multiple myeloma
OX   NCBI_TaxID=9606; ! Homo sapiens
SX   Male
CA   Cancer cell line
DT   Created: 01-12-16; Last updated: 12-03-20; Version: 6
//
RX   PubMed=21173094; DOI=10.3324/haematol.2010.033456;
RA   Moreaux J., Klein B., Bataille R., Descamps G., Maiga S., Hose D.,
RA   Goldschmidt H., Jauch A., Reme T., Jourdan M., Amiot M.,
RA   Pellat-Deceunynck C.;
RT   "A high-risk signature for patients with multiple myeloma established
RT   from the molecular classification of human myeloma cell lines.";
RL   Haematologica 96:574-582(2011).
//
RX   PubMed=30545397; DOI=10.1186/s13045-018-0679-0;
RA   Tessoulin B., Moreau-Aubry A., Descamps G., Gomez-Bougie P., Maiga S.,
RA   Gaignard A., Chiron D., Menoret E., Le Gouill S., Moreau P., Amiot M.,
RA   Pellat-Deceunynck C.;
RT   "Whole-exon sequencing of human myeloma cell lines shows mutations
RT   related to myeloma patients at relapse with major hits in the DNA
RT   regulation and repair pathways.";
RL   J. Hematol. Oncol. 11:137-137(2018).
//