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Cellosaurus MCF-7/TAX (CVCL_IJ26)

[Text version]
Cell line name MCF-7/TAX
Accession CVCL_IJ26
Resource Identification Initiative To cite this cell line use: MCF-7/TAX (RRID:CVCL_IJ26)
Comments Population: Caucasian.
Doubling time: 44.60 +- 1 hours (PubMed=24289639).
Selected for resistance to: ChEBI; CHEBI:45863; Paclitaxel (Taxol).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=24289639; DOI=10.7314/APJCP.2013.14.10.6135
Chen S.-Y., Hu S.-S., Dong Q., Cai J.-X., Zhang W.-P., Sun J.-Y., Wang T.-T., Xie J., He H.-R., Xing J.-F., Lu J., Dong Y.-L.
Establishment of paclitaxel-resistant breast cancer cell line and nude mice models, and underlying multidrug resistance mechanisms in vitro and in vivo.
Asian Pac. J. Cancer Prev. 14:6135-6140(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_IJ26
Encyclopedic resources Wikidata; Q54904385
Entry history
Entry creation01-Dec-2016
Last entry update05-Oct-2023
Version number13