Cellosaurus cell line Lymph4-AD2-iPS (CVCL_IK95)

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Cell line name	Lymph4-AD2-iPS
Synonyms	AD2-4 iPSC
Accession	CVCL_IK95
Resource Identification Initiative	To cite this cell line use: Lymph4-AD2-iPS (RRID:CVCL_IK95)
Comments	From: Heinrich-Heine-Universitat Dusseldorf; Dusseldorf; Germany. Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV). Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations	Mutation; HGNC; 17761; TREM2; Simple; p.Arg47His (c.140G>A); ClinVar=VCV000195350; Zygosity=Heterozygous (PubMed=27789408).
Disease	Alzheimer's disease 17 (NCIt: C169104) Early-onset autosomal dominant Alzheimer disease (ORDO: Orphanet_1020)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Female
Age at sampling	67Y
Category	Induced pluripotent stem cell
Publications	PubMed=27789408; DOI=10.1016/j.scr.2016.10.005 Schroter F., Sleegers K., Cuyvers E., Bohndorf M., Wruck W., Van Broeckhoven C., Adjaye J. Lymphoblast-derived integration-free iPS cell line from a female 67-year-old Alzheimer's disease patient with TREM2 (R47H) missense mutation. Stem Cell Res. 17:553-555(2016)
Cell line databases/resources	SKIP; SKIP003220
Encyclopedic resources	Wikidata; Q54608717
Entry history
Entry creation	01-Dec-2016
Last entry update	29-Jun-2023
Version number	12