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Cellosaurus SKM-1/HHT (CVCL_IM24)

[Text version]
Cell line name SKM-1/HHT
Accession CVCL_IM24
Resource Identification Initiative To cite this cell line use: SKM-1/HHT (RRID:CVCL_IM24)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI:71019; Omacetaxine mepesuccinate (Homoharringtonine; HHT).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Mutation; HGNC; 25657; BCORL1; Simple; c.4619-1G>A; Zygosity=Homozygous; Note=Splice acceptor mutation (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Lys117Asn (c.351A>C); ClinVar=VCV000375965; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Adult acute myeloid leukemia (NCIt: C9154)
Myelodysplastic syndrome (NCIt: C3247)
Acute myeloid leukemia (ORDO: Orphanet_519)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0098 (SKM-1)
Sex of cell Male
Age at sampling 76Y
Category Cancer cell line
Publications

PubMed=22967374; DOI=10.3760/cma.j.issn.0253-2727.2012.06.001
Zhou F., Tan W., Ma Y., Chen B.-B., Zhu P., Xu X.-P., Lin G.-W.
Establishment of human homoharringtonine-resistant SKM-1 cell line and its biological characteristics.
Zhonghua Xue Ye Xue Za Zhi 33:433-438(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_IM24
Encyclopedic resources Wikidata; Q54954747
Entry history
Entry creation01-Dec-2016
Last entry update05-Oct-2023
Version number13