Cellosaurus SK-MEL-28DDR1-PLXAZD (CVCL_IM75)

Cell line name SK-MEL-28DDR1-PLXAZD
Synonyms SkMel28DDR1-PLXAZD
Accession CVCL_IM75
Resource Identification Initiative To cite this cell line use: SK-MEL-28DDR1-PLXAZD (RRID:CVCL_IM75)
Comments Selected for resistance to: ChEBI; CHEBI:90227; Selumetinib (AZD6244).
Selected for resistance to: ChEBI; CHEBI:63637; Vemurafenib (Zelboraf; PLX4032).
Sequence variations Homozygous for BRAF p.Val600Glu (c.1799T>A) (from parent cell line).
Heterozygous for CDK4 p.Arg24Cys (from parent cell line).
Homozygous for EGFR p.Pro753Ser (from parent cell line).
Homozygous for TP53 p.Leu145Arg (from parent cell line).
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0526 (SK-MEL-28)
Sex of cell Male
Age at sampling 51Y
Category Cancer cell line

PubMed=26359985; DOI=10.1016/j.cell.2015.07.061
Hugo W., Shi H., Sun L., Piva M., Song C., Kong X., Moriceau G., Hong A., Dahlman K.B., Johnson D.B., Sosman J.A., Ribas A., Lo R.S.
Non-genomic and immune evolution of melanoma acquiring MAPKi resistance.
Cell 162:1271-1285(2015)

Gene expression databases GEO; GSM1588921