Cellosaurus SK-MEL-28R1-PLX (CVCL_IM76)

Cell line name SK-MEL-28R1-PLX
Synonyms SkMel28R1-PLX
Accession CVCL_IM76
Resource Identification Initiative To cite this cell line use: SK-MEL-28R1-PLX (RRID:CVCL_IM76)
Comments Selected for resistance to: ChEBI; CHEBI:63637; Vemurafenib (Zelboraf; PLX4032).
Sequence variation: Homozygous for BRAF p.Val600Glu (from parent cell line).
Sequence variation: Heterozygous for CDK4 p.Arg24Cys (from parent cell line).
Sequence variation: Homozygous for EGFR p.Pro753Ser (from parent cell line).
Sequence variation: Homozygous for TP53 p.Leu145Arg (from parent cell line).
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0526 (SK-MEL-28)
Sex of cell Male
Category Cancer cell line
Publications

PubMed=26359985; DOI=10.1016/j.cell.2015.07.061
Hugo W., Shi H., Sun L., Piva M., Song C., Kong X., Moriceau G., Hong A., Dahlman K.B., Johnson D.B., Sosman J.A., Ribas A., Lo R.S.
Non-genomic and immune evolution of melanoma acquiring MAPKi resistance.
Cell 162:1271-1285(2015)

Cross-references
Gene expression databases GEO; GSM1588920