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Cellosaurus MDA-MB-231 ERalpha (CVCL_IN17)

[Text version]

Cell line name MDA-MB-231 ERalpha
Synonyms MDA Mb231 (ERa)
Accession CVCL_IN17
Resource Identification Initiative To cite this cell line use: MDA-MB-231 ERalpha (RRID:CVCL_IN17)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Transfected with: HGNC; 3467; ESR1.
Omics: Transcriptome analysis.
Sequence variations Heterozygous for BRAF p.Gly464Val (c.1391G>T) (ClinVar=VCV000040364) (from parent cell line).
Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for KRAS p.Gly13Asp (c.38G>A) (ClinVar=VCV000012580) (from parent cell line).
TERT c.228C>T (-124C>T); in promoter (from parent cell line).
Homozygous for TP53 p.Arg280Lys (c.839G>A) (ClinVar=VCV000376657) (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0062 (MDA-MB-231)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line

PubMed=19321454; DOI=10.1074/jbc.M900365200
Nott S.L., Huang Y., Li X., Fluharty B.R., Qiu X., Welshons W.V., Yeh S., Muyan M.
Genomic responses from the estrogen-responsive element-dependent signaling pathway mediated by estrogen receptor alpha are required to elicit cellular alterations.
J. Biol. Chem. 284:15277-15288(2009)

Gene expression databases GEO; GSM246273
GEO; GSM246274
GEO; GSM246275
GEO; GSM246276
GEO; GSM246277
GEO; GSM246278
Other Wikidata; Q54904583
Entry history
Entry creation01-Dec-2016
Last entry update02-Jul-2020
Version number8