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Cellosaurus IGROV-1/CP (CVCL_IQ21)

Cell line name IGROV-1/CP
Accession CVCL_IQ21
Resource Identification Initiative To cite this cell line use: IGROV-1/CP (RRID:CVCL_IQ21)
Comments Selected for resistance to: ChEBI; CHEBI:27899; Cisplatin (CDDP).
Omics: Deep proteome analysis.
Omics: Deep RNAseq analysis.
Sequence variations Heterozygous for BRCA1 p.Lys654fs*47 (c.1961delA) (from parent cell line).
Heterozygous for SMAD4 p.Gly231fs*10 (c.692delG) (from parent cell line).
Heterozygous for PTEN p.Thr319fs*1 (c.955_958delACTT) (from parent cell line).
Heterozygous for TP53 p.Tyr126Cys (c.377A>G) (from parent cell line).
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1304 (IGROV-1)
Sex of cell Female
Age at sampling 47Y
Category Cancer cell line

PubMed=16319398; DOI=10.1074/mcp.M500140-MCP200
Stewart J.J., White J.T., Yan X., Collins S., Drescher C.W., Urban N.D., Hood L.E., Lin B.-Y.
Proteins associated with cisplatin resistance in ovarian cancer cells identified by quantitative proteomic technology and integrated with mRNA expression levels.
Mol. Cell. Proteomics 5:433-443(2006)

PubMed=23913215; DOI=10.1007/978-1-62703-547-7_12
Li L.-S., Liu J., Yu W., Lou X.-Y., Huang B.-D., Lin B.-Y.
Deep transcriptome profiling of ovarian cancer cells using next-generation sequencing approach.
Methods Mol. Biol. 1049:139-169(2013)

PubMed=27561551; DOI=10.1038/ncomms12645
Coscia F., Watters K.M., Curtis M., Eckert M.A., Chiang C.Y., Tyanova S., Montag A., Lastra R.R., Lengyel E., Mann M.
Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status.
Nat. Commun. 7:12645-12645(2016)

Other Wikidata; Q54897385