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Cellosaurus Hs578T-Dox (CVCL_IR02)

[Text version]

Cell line name Hs578T-Dox
Synonyms Hs578T/Doxo
Accession CVCL_IR02
Resource Identification Initiative To cite this cell line use: Hs578T-Dox (RRID:CVCL_IR02)
Comments Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from sampling site: Breast.
Sequence variations Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; 5173; HRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012612; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Val157Phe (c.469G>T); ClinVar=VCV000012353; Zygosity=Homozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0332 (Hs 578T)
Sex of cell Female
Age at sampling 74Y
Category Cancer cell line

de la Torre M., Hao X.-Y., Larsson R., Nygren P., Tsuruo T., Mannervik B., Bergh J.
Characterization of four doxorubicin adapted human breast cancer cell lines with respect to chemotherapeutic drug sensitivity, drug resistance associated membrane proteins and glutathione transferases.
Anticancer Res. 13:1425-1430(1993)

PubMed=10571255; DOI=10.1016/S0006-2952(99)00262-2
Jonsson O., Behnam-Motlagh P., Persson M., Henriksson R., Grankvist K.
Increase in doxorubicin cytotoxicity by carvedilol inhibition of P-glycoprotein activity.
Biochem. Pharmacol. 58:1801-1806(1999)

PubMed=15239129; DOI=10.1002/ijc.20300
Cai C.-X., Chen J.-W.
Overexpression of caveolin-1 induces alteration of multidrug resistance in Hs578T breast adenocarcinoma cells.
Int. J. Cancer 111:522-529(2004)

Encyclopedic resources Wikidata; Q54896337
Entry history
Entry creation03-Mar-2017
Last entry update20-May-2021
Version number10