Cellosaurus cell line SF7761 (CVCL_IT45)

• Mutation; HGNC; 4764; H3-3A; Simple; p.Lys28Met (c.83A>T) (H3.3K27M); ClinVar=VCV000376435; Zygosity=Unspecified (PubMed=23603901; PubMed=34732238).
  
• Mutation; HGNC; 9277; PPM1D; Simple; p.Glu540Ter (c.1618G>T); Zygosity=Unspecified (PubMed=32229503; PubMed=34732238).
  

PubMed=22983601; DOI=10.1007/s11060-012-0973-6
Hashizume R., Smirnov I., Liu S., Phillips J.J., Hyer J.D., McKnight T.R., Wendland M., Prados M.D., Banerjee A., Nicolaides T., Mueller S., James C.D., Gupta N.
Characterization of a diffuse intrinsic pontine glioma cell line: implications for future investigations and treatment.
J. Neurooncol. 110:305-313(2012)

PubMed=23603901; DOI=10.1101/gad.217778.113
Chan K.-M., Fang D., Gan H.-Y., Hashizume R., Yu C.-H., Schroeder M., Gupta N., Mueller S., James C.D., Jenkins R.B., Sarkaria J., Zhang Z.-G.
The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression.
Genes Dev. 27:985-990(2013)

PubMed=25939062; DOI=10.1038/nm.3855
Grasso C.S., Tang Y.-J., Truffaux N., Berlow N.E., Liu L.-N., Debily M.-A., Quist M.J., Davis L.E., Huang E.C., Woo P.J., Ponnuswami A., Chen S., Johung T.B., Sun W.-C., Kogiso M., Du Y.-C., Qi L., Huang Y.-L., Hutt-Cabezas M., Warren K.E., Le Dret L., Meltzer P.S., Mao H., Quezado M., van Vuurden D.G., Abraham J., Fouladi M., Svalina M.N., Wang N., Hawkins C., Nazarian J., Alonso M.M., Raabe E.H., Hulleman E., Spellman P.T., Li X.-N., Keller C., Pal R., Grill J., Monje M.
Functionally defined therapeutic targets in diffuse intrinsic pontine glioma.
Nat. Med. 21:555-559(2015)

PubMed=26115193; DOI=10.1097/NEN.0000000000000216
Taylor I.C., Hutt-Cabezas M., Brandt W.D., Kambhampati M., Nazarian J., Chang H.T., Warren K.E., Eberhart C.G., Raabe E.H.
Disrupting NOTCH slows diffuse intrinsic pontine glioma growth, enhances radiation sensitivity, and shows combinatorial efficacy with bromodomain inhibition.
J. Neuropathol. Exp. Neurol. 74:778-790(2015)

PubMed=32229503; DOI=10.1158/1541-7786.MCR-19-0507
Wang Z.-H., Xu C., Diplas B.H., Moure C.J., Chen C.-P.J., Chen L.H., Du C.-Z., Zhu H.-S., Greer P.K., Zhang L.-W., He Y.-P., Waitkus M.S., Yan H.
Targeting mutant PPM1D sensitizes diffuse intrinsic pontine glioma cells to the PARP inhibitor olaparib.
Mol. Cancer Res. 18:968-980(2020)

PubMed=34732238; DOI=10.1186/s40478-021-01270-y
Xu C., Liu H., Pirozzi C.J., Chen L.H., Greer P.K., Diplas B.H., Zhang L.-W., Waitkus M.S., He Y.-P., Yan H.
TP53 wild-type/PPM1D mutant diffuse intrinsic pontine gliomas are sensitive to a MDM2 antagonist.
Acta Neuropathol. Commun. 9:178.1-178.12(2021)