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Cellosaurus SF8628 (CVCL_IT46)

[Text version]
Cell line name SF8628
Synonyms SF-8628
Accession CVCL_IT46
Resource Identification Initiative To cite this cell line use: SF8628 (RRID:CVCL_IT46)
Comments Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Brainstem, pons; UBERON=UBERON_0000988.
Sequence variations
  • Mutation; HGNC; 4764; H3-3A; Simple; p.Lys28Met (c.83A>T) (H3.3K27M); ClinVar=VCV000376435; Zygosity=Unspecified (PubMed=23603901).
Disease Diffuse intrinsic pontine glioma (NCIt: C94764)
Diffuse intrinsic pontine glioma (ORDO: Orphanet_497188)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): Millipore

Markers:
AmelogeninX
CSF1PO11,12
D3S135815,18
D5S81811,12
D7S82011
D8S117910,13
D13S3179
D16S5399
D18S5114
D21S1129,30
FGA19,22
Penta D11,12
Penta E11,13
TH017
TPOX8
vWA16,17

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Publications

PubMed=23603901; DOI=10.1101/gad.217778.113
Chan K.-M., Fang D., Gan H.-Y., Hashizume R., Yu C.-H., Schroeder M., Gupta N., Mueller S., James C.D., Jenkins R.B., Sarkaria J., Zhang Z.-G.
The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression.
Genes Dev. 27:985-990(2013)

PubMed=24305702; DOI=10.1093/neuonc/not220
Mueller S., Hashizume R., Yang X.-D., Kolkowitz I., Olow A.K., Phillips J.J., Smirnov I., Tom M.W., Prados M.D., James C.D., Berger M.S., Gupta N., Haas-Kogan D.A.
Targeting Wee1 for the treatment of pediatric high-grade gliomas.
Neuro-oncol. 16:352-360(2014)

PubMed=29760046; DOI=10.1158/0008-5472.CAN-17-3691
Pal S., Kozono D., Yang X.-D., Fendler W., Fitts W., Ni J., Alberta J.A., Zhao J., Liu K.X., Bian J., Truffaux N., Weiss W.A., Resnick A.C., Bandopadhayay P., Ligon K.L., DuBois S.G., Mueller S., Chowdhury D., Haas-Kogan D.A.
Dual HDAC and PI3K inhibition abrogates NFkappaB- and FOXM1-mediated DNA damage response to radiosensitize pediatric high-grade gliomas.
Cancer Res. 78:4007-4021(2018)

Cross-references
Cell line collections (Providers) Millipore; SCC127
Cell line databases/resources cancercelllines; CVCL_IT46
Encyclopedic resources Wikidata; Q54952963
Gene expression databases GEO; GSE59366
GEO; GSE59496
GEO; GSM1508949
GEO; GSM1508952
Polymorphism and mutation databases Cosmic; 1925953
Entry history
Entry creation03-Mar-2017
Last entry update05-Oct-2023
Version number12