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Cellosaurus MCF-7 TKi-R (CVCL_IU98)

Cell line name MCF-7 TKi-R
Synonyms MCF-7_TKi-R
Accession CVCL_IU98
Resource Identification Initiative To cite this cell line use: MCF-7 TKi-R (RRID:CVCL_IU98)
Comments Selected for resistance to: ChEBI; CHEBI:91329; AZD8055.
Sequence variations MTOR p.Met2327Ile (c.6981G>A) (PubMed=27279227).
Heterozygous for PIK3CA p.Glu545Lys (c.1633G>A) (from parent cell line).
Disease Invasive ductal carcinoma, not otherwise specified (NCIt: C4194)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line

PubMed=27279227; DOI=10.1038/nature17963
Rodrik-Outmezguine V.S., Okaniwa M., Yao Z., Novotny C.J., McWhirter C., Banaji A., Won H., Wong W., Berger M., de Stanchina E., Barratt D.G., Cosulich S., Klinowska T., Rosen N., Shokat K.M.
Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor.
Nature 534:272-276(2016)

Other Wikidata; Q54904327
Polymorphism and mutation databases Cosmic; 2553506