ID   MCF-7 TKi-R
AC   CVCL_IU98
SY   MCF-7_TKi-R
DR   cancercelllines; CVCL_IU98
DR   Cosmic; 2553506
DR   Cosmic; 2842290
DR   Wikidata; Q54904327
RX   PubMed=27279227;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:91329; AZD8055.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3942; MTOR; Simple; p.Met2327Ile (c.6981G>A); ClinVar=VCV000242349; Zygosity=Unspecified; Note=Acquired during resistance selection process (PubMed=27279227).
CC   Sequence variation: Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0031 ! MCF-7
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 03-03-17; Last updated: 05-10-23; Version: 13
//
RX   PubMed=27279227; DOI=10.1038/nature17963;
RA   Rodrik-Outmezguine V.S., Okaniwa M., Yao Z., Novotny C.J.,
RA   McWhirter C., Banaji A., Won H., Wong W., Berger M., de Stanchina E.,
RA   Barratt D.G., Cosulich S., Klinowska T., Rosen N., Shokat K.M.;
RT   "Overcoming mTOR resistance mutations with a new-generation mTOR
RT   inhibitor.";
RL   Nature 534:272-276(2016).
//