ID   GM16530
AC   CVCL_IW03
DR   CLO; CLO_0017581
DR   Coriell; GM16530
DR   Wikidata; Q54848626
RX   PubMed=8078883;
CC   Characteristics: Cytoplasmic transfer (cybrid) produced by the fusion of Leigh syndrome enucleated cells GM13740 (Cellosaurus=CVCL_8A62) with cell line devoid of mitochondrial DNA (rho0) derived from 143B (Cellosaurus=CVCL_2270).
DI   NCIt; C84814; Leigh disease
DI   ORDO; Orphanet_506; Leigh syndrome
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_2270 ! 143B
HI   CVCL_8A62 ! GM13740
CA   Hybrid cell line
DT   Created: 03-03-17; Last updated: 21-03-23; Version: 4
//
RX   PubMed=8078883; DOI=10.1073/pnas.91.18.8334;
RA   Trounce I.A., Neill S., Wallace D.C.;
RT   "Cytoplasmic transfer of the mtDNA nt 8993 T-->G (ATP6) point mutation
RT   associated with Leigh syndrome into mtDNA-less cells demonstrates
RT   cosegregation with a decrease in state III respiration and ADP/O
RT   ratio.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:8334-8338(1994).
//