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Cellosaurus SKMEL5/R (CVCL_IW12)

[Text version]
Cell line name SKMEL5/R
Accession CVCL_IW12
Resource Identification Initiative To cite this cell line use: SKMEL5/R (RRID:CVCL_IW12)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:90295; PLX-4720 (PLX4720).
Derived from site: Metastatic; Axillary lymph node; UBERON=UBERON_0001097.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.242_243CC>TT (-138/-139CC>TT); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0527 (SK-MEL-5)
Sex of cell Female
Age at sampling 24Y
Category Cancer cell line
Publications

PubMed=26365896; DOI=10.1016/j.molonc.2015.08.003
Baenke F., Chaneton B., Smith M., van den Broek N., Hogan K., Tang H.-R., Viros A., Martin M., Galbraith L., Girotti M.R., Dhomen N., Gottlieb E., Marais R.
Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells.
Mol. Oncol. 10:73-84(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_IW12
Encyclopedic resources Wikidata; Q54954749
Entry history
Entry creation03-Mar-2017
Last entry update05-Oct-2023
Version number12