ID   C2ABR
AC   CVCL_IW75
SY   Control 2 Australia BRisbane
DR   Wikidata; Q54808116
RX   PubMed=1944384;
RX   PubMed=2836804;
RX   PubMed=6504056;
RX   PubMed=7433105;
RX   PubMed=9150358;
RX   PubMed=11080496;
RX   PubMed=17347666;
RX   PubMed=17562789;
RX   PubMed=19643912;
RX   PubMed=25868131;
CC   From: Queensland Institute of Medical Research; Brisbane; Australia.
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   69Y
CA   Transformed cell line
DT   Created: 03-03-17; Last updated: 29-06-23; Version: 8
//
RX   PubMed=1944384; DOI=10.1016/0921-8734(91)90029-B;
RA   Chen P., Kidson C., Lavin M.F.;
RT   "Heterogeneity in Alzheimer's disease: evidence from cellular
RT   radiosensitivity and complementation of this phenotype.";
RL   Mutat. Res. 256:21-27(1991).
//
RX   PubMed=2836804; DOI=10.1093/nar/16.9.3919;
RA   Singh S.P., Mohamed R., Salmond C., Lavin M.F.;
RT   "Reduced DNA topoisomerase II activity in ataxia-telangiectasia
RT   cells.";
RL   Nucleic Acids Res. 16:3919-3929(1988).
//
RX   PubMed=6504056; DOI=10.1016/0027-5107(84)90149-0;
RA   Chen P., Imray F.P., Kidson C.;
RT   "Gene dosage and complementation analysis of ataxia telangiectasia
RT   lymphoblastoid cell lines assayed by induced chromosome
RT   aberrations.";
RL   Mutat. Res. 129:165-172(1984).
//
RX   PubMed=7433105; DOI=10.1093/nar/8.16.3709;
RA   Houldsworth J., Lavin M.F.;
RT   "Effect of ionizing radiation on DNA synthesis in ataxia
RT   telangiectasia cells.";
RL   Nucleic Acids Res. 8:3709-3720(1980).
//
RX   PubMed=9150358; DOI=10.1038/sj.onc.1201037;
RA   Watters D., Khanna K.K., Beamish H.J., Birrell G., Spring K., Kedar P.,
RA   Gatei M., Stenzel D., Hobson K., Kozlov S., Zhang N., Farrell A.,
RA   Ramsay J., Gatti R.A., Lavin M.F.;
RT   "Cellular localisation of the ataxia-telangiectasia (ATM) gene product
RT   and discrimination between mutated and normal forms.";
RL   Oncogene 14:1911-1921(1997).
//
RX   PubMed=11080496; DOI=10.1074/jbc.M006190200;
RA   Gueven N., Keating K.E., Chen P., Fukao T., Khanna K.K., Watters D.,
RA   Rodemann P.H., Lavin M.F.;
RT   "Epidermal growth factor sensitizes cells to ionizing radiation by
RT   down-regulating protein mutated in ataxia-telangiectasia.";
RL   J. Biol. Chem. 276:8884-8891(2001).
//
RX   PubMed=17347666; DOI=10.1038/sj.cdd.4402116;
RA   Gueven N., Becherel O.J., Howe O., Chen P., Haince J.-F., Ouellet M.-E.,
RA   Poirier G.G., Waterhouse N., Fusser M., Epe B., de Murcia J.M.,
RA   de Murcia G., McGowan C.H., Parton R., Mothersill C.,
RA   Grattan-Smith P., Lavin M.F.;
RT   "A novel form of ataxia oculomotor apraxia characterized by oxidative
RT   stress and apoptosis resistance.";
RL   Cell Death Differ. 14:1149-1161(2007).
//
RX   PubMed=17562789; DOI=10.1083/jcb.200701042;
RA   Suraweera A., Becherel O.J., Chen P., Rundle N., Woods R.,
RA   Nakamura J., Gatei M., Criscuolo C., Filla A., Chessa L., Fusser M.,
RA   Epe B., Gueven N., Lavin M.F.;
RT   "Senataxin, defective in ataxia oculomotor apraxia type 2, is involved
RT   in the defense against oxidative DNA damage.";
RL   J. Cell Biol. 177:969-979(2007).
//
RX   PubMed=19643912; DOI=10.1093/hmg/ddp359;
RA   Harris J.L., Jakob B., Taucher-Scholz G., Dianov G.L., Becherel O.J.,
RA   Lavin M.F.;
RT   "Aprataxin, poly-ADP ribose polymerase 1 (PARP-1) and apurinic
RT   endonuclease 1 (APE1) function together to protect the genome against
RT   oxidative damage.";
RL   Hum. Mol. Genet. 18:4102-4117(2009).
//
RX   PubMed=25868131; DOI=10.1016/j.mrgentox.2015.03.012;
RA   Kobayashi J., Saito Y., Okui M., Miwa N., Komatsu K.;
RT   "Increased oxidative stress in AOA3 cells disturbs ATM-dependent DNA
RT   damage responses.";
RL   Mutat. Res. 782:42-50(2015).
//