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Cellosaurus HepG2 CYP3A4G/7R clone 87 (CVCL_IX10)

[Text version]

Cell line name HepG2 CYP3A4G/7R clone 87
Synonyms HepG2 C87; C87
Accession CVCL_IX10
Resource Identification Initiative To cite this cell line use: HepG2 CYP3A4G/7R clone 87 (RRID:CVCL_IX10)
Comments Population: Caucasian.
Characteristics: Transfected with a dual reporter that express RFP under the transcriptional regulation of CYP3A7 in the hepatoblast-like cell state and EGFP under the transcriptional regulation of CYP3A4.
Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP).
Transfected with: UniProtKB; Q9U6Y8; RFP.
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Derived from sampling site: Liver.
Sequence variations Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line

PubMed=25101946; DOI=10.1371/journal.pone.0104123
Tsuji S., Kawamura F., Kubiura M., Hayashi A., Ohbayashi T., Kazuki Y., Chesne C., Oshimura M., Tada M.
Dual-color fluorescence imaging to monitor CYP3A4 and CYP3A7 expression in human hepatic carcinoma HepG2 and HepaRG cells.
PLoS ONE 9:E104123-E104123(2014)

Other Wikidata; Q54882844
Entry history
Entry creation22-Aug-2017
Last entry update20-May-2021
Version number10