ID   HepG2 CYP3A4G/7R clone 87
AC   CVCL_IX10
SY   HepG2 C87; C87
DR   cancercelllines; CVCL_IX10
DR   Wikidata; Q54882844
RX   PubMed=25101946;
CC   Population: Caucasian.
CC   Characteristics: Transfected with a dual reporter that express RFP under the transcriptional regulation of CYP3A7 in the hepatoblast-like cell state and EGFP under the transcriptional regulation of CYP3A4.
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP).
CC   Transfected with: UniProtKB; Q9U6Y8; Discosoma sp. red fluorescent protein drFP583 (DsRed, RFP).
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C3728; Hepatoblastoma
DI   ORDO; Orphanet_449; Hepatoblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0027 ! Hep-G2
SX   Male
AG   15Y
CA   Cancer cell line
DT   Created: 22-08-17; Last updated: 05-10-23; Version: 13
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RX   PubMed=25101946; DOI=10.1371/journal.pone.0104123;
RA   Tsuji S., Kawamura F., Kubiura M., Hayashi A., Ohbayashi T.,
RA   Kazuki Y., Chesne C., Oshimura M., Tada M.;
RT   "Dual-color fluorescence imaging to monitor CYP3A4 and CYP3A7
RT   expression in human hepatic carcinoma HepG2 and HepaRG cells.";
RL   PLoS ONE 9:E104123-E104123(2014).
//