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Cellosaurus NB4R (CVCL_IY15)

[Text version]

Cell line name NB4R
Accession CVCL_IY15
Resource Identification Initiative To cite this cell line use: NB4R (RRID:CVCL_IY15)
Comments Selected for resistance to: ChEBI; CHEBI:15367; All-trans-retinoic acid (ATRA; Tretinoin).
Derived from sampling site: Bone marrow.
Sequence variations Gene fusion; HGNC; 9113; PML + HGNC; 9864; RARA; Name(s)=PML-RARA (from parent cell line).
Mutation; HGNC; 6407; KRAS; Simple; p.Ala18Asp (c.53C>A); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Acute promyelocytic leukemia with PML-RARA (NCIt: C3182)
Acute promyelocytic leukemia (ORDO: Orphanet_520)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0005 (NB4)
Sex of cell Female
Age at sampling 23Y
Category Cancer cell line
Publications

Patent=US5589345
Lanotte M., Berger R.
Cultures of permanent lines of human promyelocytic cells and their uses for the screening of molecules utilizable in particular in the treatment of leukemias.
Patent number US5589345, 31-Dec-1996

Cross-references
Other Wikidata; Q54907540
Entry history
Entry creation15-May-2017
Last entry update20-May-2021
Version number11