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Cellosaurus MDCK-P-gp (CVCL_IZ19)

[Text version]

Cell line name MDCK-P-gp
Accession CVCL_IZ19
Resource Identification Initiative To cite this cell line use: MDCK-P-gp (RRID:CVCL_IZ19)
Comments Characteristics: Developed to assess drugs as substrates for p-glycoprotein (ABCB1/MDR). Expresses high level of ABCB1/MDR1.
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from sampling site: Kidney.
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Breed/subspecies: Cocker Spaniel.
Hierarchy Parent: CVCL_0422 (MDCK)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=28093773; DOI=10.1111/jvp.12390
Mealey K.L., Dassanayake S., Burke N.S.
Establishment of a cell line for assessing drugs as canine P-glycoprotein substrates: proof of principle.
J. Vet. Pharmacol. Ther. 40:545-551(2017)

Cross-references
Other Wikidata; Q54904786
Entry history
Entry creation15-May-2017
Last entry update19-Dec-2019
Version number4