ID   LS174T-W4
AC   CVCL_J074
SY   Ls174T-W4; W4
DR   cancercelllines; CVCL_J074
DR   Wikidata; Q54903056
RX   PubMed=19386264;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (from parent cell line).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
CC   Cell type: Epithelial cell of colon; CL=CL_0011108.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1384 ! LS174T
SX   Female
AG   58Y
CA   Cancer cell line
DT   Created: 11-02-13; Last updated: 05-10-23; Version: 16
//
RX   PubMed=19386264; DOI=10.1016/j.devcel.2009.01.016;
RA   ten Klooster J.P., Jansen M., Yuan J., Oorschot V.M.J., Begthel H.,
RA   Di Giacomo V., Colland F., de Koning J.P., Maurice M.M., Hornbeck P.,
RA   Clevers H.C.;
RT   "Mst4 and ezrin induce brush borders downstream of the Lkb1/Strad/Mo25
RT   polarization complex.";
RL   Dev. Cell 16:551-562(2009).
//