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Cellosaurus J-beta2.7 (CVCL_J124)

[Text version]

Cell line name J-beta2.7
Synonyms J-(beta2).7; Jurkat-beta2.7; Jurkat B2.7; J-B2.7; B2.7
Accession CVCL_J124
Resource Identification Initiative To cite this cell line use: J-beta2.7 (RRID:CVCL_J124)
Comments Derived from sampling site: Peripheral blood.
Sequence variations Heterozygous for BAX p.Glu41Argfs*19 (c.121delG) (ClinVar=VCV000009512) (from parent cell line).
Heterozygous for BAX p.Glu41Glyfs*33 (c.121dupG) (ClinVar=VCV000009511) (from parent cell line).
Heterozygous for FBXW7 p.Arg505Cys (c.1513C>T) (ClinVar=VCV000069961) (from parent cell line).
Heterozygous for INPP5D p.Gln345Ter (c.1033C>T) (from parent cell line).
Heterozygous for INPP5D c.1097+1065_1097+1112del47 (from parent cell line).
Homozygous for MSH2 p.Arg711Ter (c.2131C>T) (ClinVar=VCV000090903) (from parent cell line).
Homozygous for MSH6 p.Phe1088Serfs*2 (c.3261delC) (ClinVar=VCV000089363) (from parent cell line).
Heterozygous for SYK p.Met34Hisfs*3 (c.98_99insG) (from parent cell line).
Heterozygous for TP53 p.Arg196Ter (c.586C>T) (ClinVar=VCV000043589) (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0367 (Jurkat E6.1)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
Publications

PubMed=8977199
Weber K.S., York M.R., Springer T.A., Klickstein L.B.
Characterization of lymphocyte function-associated antigen 1 (LFA-1)-deficient T cell lines: the alphaL and beta2 subunits are interdependent for cell surface expression.
J. Immunol. 158:273-279(1997)

Cross-references
Other Wikidata; Q54898412
Entry history
Entry creation11-Feb-2013
Last entry update12-Jan-2021
Version number15