ID   FU-266 clone E1
AC   CVCL_J236
SY   FU-266 (E1)
DR   Wikidata; Q54835232
RX   Patent=US4574116;
RX   PubMed=6316357;
CC   Population: Caucasian.
CC   Characteristics: Produces IgE lambda (from parent cell line).
CC   Selected for resistance to: ChEBI; CHEBI:9555; Tioguanine (6-thioguanine; 6-TG).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Lys601Asn (c.1803A>T); ClinVar=VCV000376285; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7329; MSH6; Simple; p.Gly141Asp (c.422G>A); ClinVar=VCV001491786; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Ala161Thr (c.481G>A); ClinVar=VCV000161518; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 12033; TRAF3; Simple; p.Lys550Leufs*3 (c.1648_1649insT); Zygosity=Homozygous (from parent cell line).
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C3242; Plasma cell myeloma
DI   ORDO; Orphanet_29073; Multiple myeloma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_J235 ! FU-266
SX   Male
AG   53Y
CA   Cancer cell line
DT   Created: 11-02-13; Last updated: 05-10-23; Version: 13
//
RX   Patent=US4574116;
RA   Kaplan H.S., Teng N.N.H., Lam K.S., Calvo-Riera F.;
RT   "Methods and cell lines for immortalization and monoclonal antibody
RT   production by antigen-stimulated B-lymphocytes.";
RL   Patent number US4574116, 04-Mar-1986.
//
RX   PubMed=6316357; DOI=10.1073/pnas.80.23.7308;
RA   Teng N.N.H., Lam K.S., Calvo Riera F., Kaplan H.S.;
RT   "Construction and testing of mouse -- human heteromyelomas for human
RT   monoclonal antibody production.";
RL   Proc. Natl. Acad. Sci. U.S.A. 80:7308-7312(1983).
//