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Cellosaurus CEM-SS (CVCL_J318)

[Text version]

Cell line name CEM-SS
Synonyms CEM-ss; CEM SS; CEM_SS; CEMss; CEM-Syncitial Sensitive
Accession CVCL_J318
Resource Identification Initiative To cite this cell line use: CEM-SS (RRID:CVCL_J318)
Comments Population: Caucasian.
Characteristics: Used for a quantitative syncytium-forming assay for the detection of human immunodeficiency virus-1 and -2 isolates.
Doubling time: ~1-2 days (HIVReagentProgram).
Derived from sampling site: Peripheral blood. Cell type=T-cell.
Sequence variations
  • Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0207 (CCRF-CEM)
Children:
CVCL_WU90 (CEMss/CCR5 )CVCL_1E04 (Rev-CEM )
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line
Web pages http://www.nibsc.org/Default.aspx?pageid=597&id=0048&theme=default
http://www.aidsreagent.org/pdf_images/776_002.pdf
Publications

PubMed=3481271; DOI=10.1089/aid.1987.3.283
Nara P.L., Hatch W.C., Dunlop N.M., Robey W.G., Arthur L.O., Gonda M.A., Fischinger P.J.
Simple, rapid, quantitative, syncytium-forming microassay for the detection of human immunodeficiency virus neutralizing antibody.
AIDS Res. Hum. Retroviruses 3:283-302(1987)

PubMed=25253335; DOI=10.1128/JVI.01543-14
Herold N., Anders-Osswein M., Glass B., Eckhardt M., Muller B., Krausslich H.-G.
HIV-1 entry in SupT1-R5, CEM-ss, and primary CD4+ T cells occurs at the plasma membrane and does not require endocytosis.
J. Virol. 88:13956-13970(2014)

Cross-references
Cell line collections HIVReagentProgram; ARP-776
Cell line databases/resources TOKU-E; 4084
Chemistry resources ChEMBL-Cells; CHEMBL3307644
ChEMBL-Targets; CHEMBL614548
Encyclopedic resources Wikidata; Q54809255
Polymorphism and mutation databases Cosmic; 1247869
Entry history
Entry creation11-Feb-2013
Last entry update23-Jun-2022
Version number20