ID   RPMI-8226/Dox6
AC   CVCL_J432
SY   RPMI 8226/DOX6; 8226/DOX6; 8226/Dox6; DOX-6; Dox6
DR   cancercelllines; CVCL_J432
DR   Wikidata; Q54951247
RX   PubMed=2569359;
RX   PubMed=10070958;
CC   Population: African American.
CC   Characteristics: Produces IgG lambda (from parent cell line).
CC   Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
CC   Sequence variation: Gene fusion; HGNC; 5722; IGKJ4 + HGNC; 5783; IGKV2-28; Name(s)=IGKV2-28-IGKJ4 (from parent cell line).
CC   Sequence variation: Gene fusion; HGNC; 5865; IGLJ3 + HGNC; 5888; IGLV2-14; Name(s)=IGLV2-14-IGLJ3 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3236; EGFR; Simple; p.Thr751Ile (c.2252C>T); ClinVar=VCV000177773; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000045122; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Glu285Lys (c.853G>A); ClinVar=VCV000420133; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 12033; TRAF3; Simple; p.Lys191Leufs*60; Zygosity=Unspecified (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: B-cell; CL=CL_0000236.
DI   NCIt; C3242; Plasma cell myeloma
DI   ORDO; Orphanet_29073; Multiple myeloma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0014 ! RPMI-8226
SX   Male
AG   61Y
CA   Cancer cell line
DT   Created: 11-02-13; Last updated: 05-10-23; Version: 18
//
RX   PubMed=2569359;
RA   Tong A.W., Lee J., Wang R.-M., Dalton W.S., Tsuruo T., Fay J.W.,
RA   Stone M.J.;
RT   "Elimination of chemoresistant multiple myeloma clonogenic
RT   colony-forming cells by combined treatment with a plasma cell-reactive
RT   monoclonal antibody and a P-glycoprotein-reactive monoclonal
RT   antibody.";
RL   Cancer Res. 49:4829-4834(1989).
//
RX   PubMed=10070958;
RA   Hazlehurst L.A., Foley N.E., Gleason-Guzman M.C., Hacker M.P.,
RA   Cress A.E., Greenberger L.M., de Jong M.C., Dalton W.S.;
RT   "Multiple mechanisms confer drug resistance to mitoxantrone in the
RT   human 8226 myeloma cell line.";
RL   Cancer Res. 59:1021-1028(1999).
//