Cellosaurus RPMI-8226/LR-5 (CVCL_J434)

Cell line name RPMI-8226/LR-5
Synonyms RPMI-8226 LR5; RPMI8226-LR5; RPMI 8226/LR5; 8226/LR-5; 8226/LR5
Accession CVCL_J434
Resource Identification Initiative To cite this cell line use: RPMI-8226/LR-5 (RRID:CVCL_J434)
Comments Characteristics: Produces IgG lambda.
Selected for resistance to: ChEBI; CHEBI:28876; Melphalan (L-phenylalanine mustard; LPAM; Alkeran).
Derived from sampling site: Peripheral blood.
Sequence variations Heterozygous for EGFR p.Thr751Ile (c.2252C>T) (from parent cell line).
Heterozygous for KRAS p.Gly12Ala (c.35G>C) (from parent cell line).
Homozygous for TP53 p.Glu285Lys (c.853G>A) (from parent cell line).
Disease Plasma cell myeloma (NCIt: C3242)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0014 (RPMI-8226)
Sex of cell Male
Age at sampling 61Y
Category Cancer cell line
Publications

PubMed=1988143
Bellamy W.T., Dalton W.S., Gleason M.C., Grogan T.M., Trent J.M.
Development and characterization of a melphalan-resistant human multiple myeloma cell line.
Cancer Res. 51:995-1002(1991)

Cross-references
Other Wikidata; Q54951248
Proteomic databases PRIDE; PXD001276